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The Department of Medicine was established in 1930, coinciding with the opening of Duke Hospital. Types of materials include reprints; appointment lists of professors, associates, instructors, residents, affiliates, and alumni; biographical sketches; Eugene A. Stead Jr. alumni lists; a biography of Frederic Moir Hanes; lists of chief residents of Duke Hospital, VA Medical Center, and Ambulatory Care; a list of the numbers of house staff; student, house staff, and faculty files; and staff and faculty group photographs. Major subjects include the Department of Medicine. Materials date from 1930 to 2017.

Contains the personal and professional papers of Frederic Moir Hanes (1883-1946), pathologist, neurologist, and chair of the Department of Medicine at Duke University. Types of materials include correspondence, reprints, writings, budgets, minutes, scrapbooks, and memoranda. Major subjects include the Hanes Fund, Duke University School of Medicine, Department of Pathology, Department of Medicine, study and teaching of medicine in North Carolina, physicians, pathology, and the Sarah P. Duke Gardens. Materials range in date from 1909 to 1967.

Mary Duke Biddle Trent Semans (1920-2012) is a member of the Duke family and a female philanthropic leader in health care at Duke and in the Durham community. This collection contains 2 oral history interviews conducted at different times. Interviews were conducted on July 27, 2006 and August 2, 2007 by Jessica Roseberry as part of the Women in Duke Medicine Oral History Exhibit. In the 2006 interview, Semans discusses her experiences with health care at Duke and in Durham throughout her lifetime. In the 2007 interview, Semans discusses issues in women's health and women who were Duke physicians and who worked in health care in general.

Contains the personal and professional papers of Wilburt Cornell Davison (1897-1972), pediatrician, chair of pediatrics, and first dean of Duke University School of Medicine (1927-1960). Types of materials include correspondence, subject files, memorabilia, scrapbooks, photographs, clippings, programs, budgets, reports, deeds, poems, manuscript materials, creative writings, genealogical materials, article reprints, diplomas, and certificates and invitations. Oversized diplomas and certificates have been separated from this collection. Major correspondents include George G. Allen, Atala Davison, Jay M. Arena, F. Vernon Altvater, Bessie Baker, William B. Bell, William Preston Few, Wiley D. Forbus, Frederic Moir Hanes, Elizabeth Hanes, Julian Deryl Hart, Sir William Osler, Talmage Peele, Wilder Penfield, Watson S. Rankin, Josiah Trent, and Mary Duke Biddle Trent Semans. Major groups and associations in the collection include Alpha Omega Alpha, American Hospital Association, American Medical Association, Association of American Medical Colleges, Lincoln Hospital, Rockefeller Foundation, and Society for Pediatric Research. Major subjects in this collection include pediatrics, medical education, Duke University School of Medicine, Duke University faculty and students, Duke Hospital, and Private Diagnostic Clinic. Materials date from 1881 to 1972.