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During the 1970s and 1980s, Orgain's research interests included the diagnosis and treatment of endocarditis, the diagnosis and pharmacological treatment of arrhythmias and congestive heart failure, and the investigation and pharmacological therapy of hypertensive vascular disease and of coronary artery disease. Contains newsletters, lists, memoranda, and financial materials pertaining to the Cardiovascular Diseases Service and the Cardiovascular Diseases Research Fund at Duke University. Materials range in date from 1946 to 1989.

Contains materials pertaining to the history and development of the Private Diagnostic Clinic at Duke University, particularly the role of the internal medicine physicians. Types of materials include contracts, correspondence, financial materials, minutes, and memoranda. Materials range in date from 1949 to 1971.