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Materials were created by staff and artists of Medical Art, later Medical Illustration, a section of Educational Media Services, a division of the Duke University School of Medicine. Artists include Elon H. Clark, Robert L. Blake, Robert G. Gordon and Stanley M. Coffman. Types of materials include photographs, negatives, slides, sketches, and drawings. The collection also contains prints, negatives, and sketches of items created by Gordon and Coffman for David C. Sabiston's "Atlas of Cardiothoracic Surgery." Major subjects include Duke University School of Medicine and medical illustration. Materials range in date from 1950 to 2003.

Contains the historical records of the City of Medicine, a public relations and community outreach health organization based in Durham, North Carolina. Types of materials include scrapbooks, clippings, publications, reports, speeches, textiles, videotapes, photographs and memorabilia. Major subjects include Durham, North Carolina, public relations, and Duke University. Materials range in date from 1980 to 2003.

Contains the administrative records of the School of Nursing, School of Nursing Alumni Association, and other nursing student associations. Types of materials include correspondence, minutes, certificates, newsletters, budgets, evaluations, reports, class records, proceedings, publications, awards, photographs, ephemera, memorabilia, printed materials, DVDs, CDs, and clippings. Major subjects include Duke University School of Nursing students and faculty, School of Nursing Alumni Association, Nursing Student Government Association, Nursing education, continuing education, nursing students, nursing societies, sororities, Sigma Theta Tau, Bessie Baker, Rachel Booth, Myrtle Irene Brown, Dorothy Brundage, Ann Jacobansky, Margaret Pinkerton, Florence K. Wilson, and Ruby L. Wilson. Materials range in date from 1930 to 2017.

Contains the professional papers of Jay Morris Arena (1909-1996), professor of pediatrics and community health and director of the Duke Poison Control Center. Types of materials include correspondence, reports, minutes, reprints, newsletters, clippings, programs, certificates, photographs, biographical materials, and manuscript materials. Major correspondents include Wilburt Cornell Davison, Atala Davison, Talmage Peele, Thomas Thweatt Jones and members of the Duke Children's Classic advisory group. Major subjects include Duke University Hospital, pediatrics, accidental poisoning in children, poisoning prevention and safety measures, poisoning case studies, treatment of poisoning, poison control centers, American Academy of Pediatrics, Duke Poison Control Center, and pediatrics in China. Materials range in date from 1931 to 1995.

Documents the professional career of Ewald W. Busse (1917-2004), the former chair of Duke's Department of Psychiatry and founding director the Duke University Center for Aging and Human Development. The materials include Busse's "History of the Department of Psychiatry at Duke"; Busse's reprints; a history of the Duke Medical Center Building Fund; awards and honors; reports and evaluations regarding the J. B. Gibbons Scholarship; minutes, newsletters, correspondence, and publications from the International Association of Gerontology; information about Highland Hospital (Asheville, North Carolina); materials regarding the Center for the Study of Aging and Human Development; and the Medical School Advisory Committee's (MedSAC) minutes materials. Materials range in date from 1945 to 2003.

The International Correspondence Society of Allergists began in 1937 as a way to exchange technical information and experiences between allergists around the world. Contains correspondence and case reports discussing patient cases, new treatments, and professional development. Materials range in date from 1942 to 1966.

Contains the professional papers of Philip Handler (1917-1981), professor and chair of Duke University's Department of Biochemistry. Types of materials include correspondence, programs, bulletins, illustrations, exams, course materials, applications, agendas, reports, writings, clippings, speeches, tributes, invoices, reprints, biographical materials, questionnaires, and photographs. Major correspondents include Wilburt Cornell Davison, Barnes Woodhall, andWilliam A. Perlzweig. Major subjects include Duke University's Research Training Program, Cold Spring Harbor Laboratories, medical education, National Academy of Sciences, Lederle Laboratories, and Oak Ridge Laboratories. Materials date from 1933 to 1982.

Ralph Arnold (1910-1960) was a professor of otology and an associate professor of otolaryngology and ophthalmology at the Duke University Medical Center in the 1940s and 1950s. He also served as part of the 65th General Hospital during World War II. The collection consists photographs, correspondence, records pertaining to the patent Arnold received for silicone treated cotton, medical records from Arnold's time in the army, and medical equipment, at least some of which was used for the 65th General Hospital. Materials date from 1942 to 2013.

Contains records of the laboratory work and files of Huntington F. Willard, first director of the Institute for Genome Sciences and Policy at Duke University, vice Chancellor for Genome Sciences and professor in the Department of Molecular Genetics and Microbiology.

Contains records originating in Duke School of Medicine's Dean's Office. Includes R. Sanders (Sandy) Williams administrative records; a small amount of Wilburt C. Davison reprints; Medical Center Executive Committee (MCEC) meeting materials; posters from the Dean's Office Noteworthy Faculty Series comprised of posters and photographs; portraits of Edward W. Holmes and Nancy C. Andrews; and Mary E. Klotman and Duke University School of Medicine's "Turning a Moment into a Movement: Dismantling Racism in the Duke School of Medicine and Beyond" video and discussion, which is affiliated with Moments to Movement, Duke Health's collective stand against systemic racism and injustice. Materials date from 1916 to 2020.