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Duke Neurosurgery was created in 1937, although it did not become a department until July 1, 2015. Prior to becoming a department, Neurosurgery was a division under the Department of Surgery. Contains materials documenting Dr. Guy Odom and Dr. Blaine Nashold's work for Duke Neurosurgery. Types of materials include patient records, 16mm films documenting various conditions, departmental administrative records, photographs, lantern slides, surgical knives, and a Riechert Mundinger cerebral stereotaxy frame and some related surgical components. Materials dates from 1922 to 1988.

The Department of Obstetrics and Gynecology was established in 1930 as one of the founding departments at Duke University Medical Center. This collection contains articles, clippings, order forms, lectures, survey results, slides, Roy T. Parker Symposium programs, correspondence, artifacts, plaques, printed materials, photographs, negatives, and delivery and procedure logs produced by Department of Obstetrics and Gynecology faculty members from 1930 to 1995. Major contributors include F. Bayard Carter, E. C. Hamblen, and Robert A. Ross. Materials range in date from 1930 to 2018.

The Department of Ophthalmology, established in 1965, began in 1930 as a division within the Department of Surgery. Divisions of the department include Comprehensive Ophthalmology, Cornea Service, Glaucoma, Neuro-Ophthalmology, Oculoplastics, Pediatric Ophthalmology, Research Division, and Vitreoretinal Service. This collection contains publications, administrative and departmental records, reprints by faculty and staff, research files and materials, alumni files, grant information, photographs, slides, negatives, audiovisual materials, and public relations materials. The materials date from 1940 to 2014. Materials range in date from 1940 to 2014.

Duke School of Medicine's Department of Pediatrics was founded in 1927 by Wilburt C. Davison, MD, the first dean of the medical school. He also served as the first Department of Pediatrics chair (1927 to 1954). Other chairs include Jerome Harris, MD; Samuel L. Katz, MD; Michael M. Frank, MD; Joseph St. Geme, MD; and Ann M. Reed, MD. The collection documents the Department of Pediatrics with information about the department, Duke Children's Hospital, and affiliated clinics. Types of materials include departmental administrative files, financial information, planning and development materials, Duke Children's Hospital blueprints, meeting and committee materials, research files, printed materials, correspondence, reports and manuals, a small amount of audiovisual materials, grant and award information, and a list of Pediatrics House Staff. Materials date from 1930 to 2014.

The Department of Physical Therapy at Duke University was established by Helen Kaiser in 1943. In 1970, the program began awarding a Master of Science degree. In 2000, the department transferred from offering a master's degree to offering a Doctor of Physical Therapy degree. The collection contains photographs, faculty-student picnic invitations, anniversary buttons, and graduation programs. The photographs include images of students, facilities, and faculty, including Helen Kaiser. The buttons are from the 50th (1993) and 60th (2003) anniversaries of the program. Materials range in date from 1942 to 2006.

The Department of Psychiatry & Behavioral Sciences, established in 1994, focuses on understanding the brain and mind through research, clinical care, and education with the goal to help people with mental health challenges live their best life. Prior to this, the department originated as the Division of Neuropsychiatry in the Department of Medicine in 1933. In 1940 it became the Department of Neuropsychiatry, and in 1951 the name changed to the Department of Psychiatry. Contains administrative records of the Department of Psychiatry and the Department of Psychiatry & Behavioral Sciences, as well as a small amount of portraits and scrapbooks. Materials range in date from 1944 to 1992.

In 1929, Dr. Robert James Reeves was appointed Instructor of Radiology and helped form the Department of Radiology at Duke. The first radioisotope laboratory at Duke was established in 1952.The Radiation and Oncology division formed in 1978, becoming a separate department in 1989, and the Nuclear Medicine division formed in 1979. Contains staff lists, meeting minutes, correspondence, graphs, clippings, notes, speeches, brochure, newsletters, programs, slides, and photographs. Materials range in date from 1932 to 1988.

The Department of Surgery's Chief Resident Interview Project began in 2018. The interviews are conducted with Department of Surgery's Chief Residents each year as a way to document the department's Chief Residents. Interviewees discuss their family background, educational background, and experiences at Duke. Materials date from 2018 to 2022.

Established in 1930, The Department of Surgery was one of the first departments at Duke Hospital and Duke School of Medicine. The collection contains correspondence, reports, photographs, composite photographs, handbooks, invitations, microscope slides, negatives, 35mm projector slides, research notes, research logs, articles, artifacts, reference files, programs, departmental publications, financial records, and digital files documenting the day to day operations of the department. Materials range in date from 1930 to 2021.

The Duke Department of Urology is a leader in providing outstanding clinical care, performing cutting-edge clinical and basic science research, and training the next generation of outstanding clinical and academic leaders in the field of urology. The department's mission is to advance urologic health as a leader in world-class multidisciplinary research; innovative education; and compassionate, exception urologic care for all patients. Duke Urology is recognized worldwide for expertise in the areas of general urology, prostate cancer and prostatic diseases, male sexual health, urinary tract stone management through the Duke Comprehensive Kidney Stone Program, minimally invasive surgery and robotics, reconstructive urology, urinary incontinence, testicular cancer, bladder cancer, and pediatric urology. Includes materials from the Division of Urology, prior to it becoming the Department of Urology in 2023. Contains administrative records pertaining to the Duke Urologic Assembly, Duke Tuesday, Winter Urologic Forum, Focal Therapy workshops and symposiums, Duke Prostate Cancer Patient Symposiums, a small amount of correspondence and departmental printed materials, including an early urology handbook. Types of materials include programs, correspondence, digital files, brochures, and flyers. Materials date from 1969 to 2019.