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Contains files on major subjects in Lyman's career, including techniques for treating various mental illnesses, African-American patients and employees, conscientious objectors, Department of Neuropsychiatry, Highland Hospital, government-sponsored studies on motion sickness, psychiatric attendants, teaching, U.S. Public Health Grants, U.S. Veterans Administration, and areas of the Duke University Medical Center such as the Meyer Ward and the Children's Spastic Dormitory. Materials date from 1927 to 1951.

Contains correspondence with Lyman's colleagues and former students at Duke University, Johns Hopkins University, and other institutions. Also contains Lyman's correspondence related to various hospitals, schools, medical societies, associations, and conferences, laboratories, and his work with conscientious objectors during World War II. Specific Duke Departments and associated entities discussed in this correspondence include the Department of Psychology, the Duke Parapsychology Lab, and Highland Hospital. Materials date from 1940 to 1957.

Contains reports, correspondence, budgets, projections, schedules, and program information concerning Duke University Medical Center, Duke Hospital mental health clinics, and other regional mental health associations and programs. Materials date from 1942 to 1952.