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Dr. O. Michael Colvin (1936-2013) served as director of the Duke Comprehensive Cancer Center from 1995 to 2002, and as William Shingleton Professor of Cancer Research from 2002 to 2008. In addition to his administrative and educative roles, Colvin conducted pioneering research on cyclophosphamide and other alkylating agents, in the pursuit of bettering chemotherapy and tumor treatment. Among other materials, the collection contains correspondence, clippings, committee and conference materials, research notes, writings, photographs, awards, and digital files. Major subjects include Colvin's research and positions in professional organizations. Materials range in date from 1957 to 2009, with the bulk dating from 1987 to 2009.