Contains professional correspondence between Handler and colleagues at National Academy of Sciences, Lederle Laboratories, and various foundations and universities. Duke University correspondence includes materials pertaining to the Department of Biochemistry, Cold Spring Harbor Laboratories, Oak Ridge Laboratories, local disaster response planning, chair search committees, and the Research Training Program. Major correspondents include Wilburt Cornell Davison, Barnes Woodhall, and William A. Perlzweig. Materials date from 1933 to 1982.