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This series contains materials created by Sabiston at Johns Hopkins University: a sampling of operative notes showing Sabiston's approach to clinical treatments, curriculum materials, and hospital rounds notes. All personally identifiable health information has been redacted from these clinical treatment files. School of Medicine curriculum revision materials contain correspondence and other materials pertaining to a daily schedule, fees, staffing, fourth- and fifth- year curriculum planning, and some correspondence with Alfred Blalock. Materials date from 1934 to 1996.

Contains interviews and manuscript materials supporting the research and writing of the book, "At the Heart of Medicine: Essays on the Practice of Surgery and Surgical Education" by David C. Sabiston Jr. and Barton F. Haynes (2006). Also contains illustration drafts related to Chapter 31-V of the "Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice". Materials date from 1995 to 2001.

This series contains memorabilia and artifacts pertaining to David C. Sabiston Jr.'s early education, later career as a surgeon, and as a leader in medical policy and administration. Types of materials include printed materials; science research papers from high school; teaching awards; certificates of appreciation; symposia recognition items; and notes of recognition from regional and international medical schools, associations, and agencies. The series also contains artifacts including academic robes and hoods, a paperweight, and a commemorative glass. Materials date from 1938 to 2009.