Clinical Research Center for the Study of Depression in Later Life, 1984-1994

Creator:
Duke University. Center for the Study of Aging and Human Development.
Scope and content:

Includes materials pertaining to the Clinical Research Center for the Study of Depression in Later Life (CRC), which was jointly administered by the Department of Psychiatry and the Center for the Study of Aging. The first cycle of funding began in 1984. In addition to the first round of funding (10/1/84-6/30/90), two competing renewals (7/1/90-6/30/94 and 7/1/94-6/30/99) were funded for a total of 16 years of funding by National Institute of Mental Health (NIMH). As is true of most center grants, the CRC included a major or core project and a number of sub-studies. Linda K. George, PhD was affiliated with the core project, which consisted of recruiting middle aged and older (age 45 and older) in patients who were hospitalized at Duke University Medical Center (DUMC) with a diagnosis of major depressive disorder (MDD). During their hospitalizations, patients were administered a "core" interview titled the Duke Depression Evaluation Schedule (DDES). The primary contents of the DDES were a diagnostic interview to validate the diagnosis of MDD and a comprehensive social survey. A close family member or caregiver of the patient also was interviewed at baseline. Additional data were extracted from the patient's chart and medical records, including information about use of psychotropic medications and other treatments targeted at MDD (e.g., ECT). Study participants also were asked to donate a blood sample to monitor serum levels of antidepressant medications. After the baseline assessment, study participants were re-interviewed at 6 month intervals by telephone with a shortened version of the DDES. The primary purpose of the follow-up interviews was to assess the study participant's depressive symptoms because a major goal of the CRC was to identify patterns of recovery, relapse, and chronicity of MDD. Dr. Dan Blazer and Dr. Bernard J. Carroll were principal investigators of the three CRC grant proposals. Materials date from 1984 to 1994.

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This collection may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations, including the Health Insurance Portability and Accountability Act (HIPAA). Researchers are advised that the disclosure of certain information pertaining to identifiable individuals represented in this collection without the consent of those individuals or IRB approval may have legal ramifications (e.g., a cause of action under common law for invasion of privacy may arise if facts concerning an individual's private life are published that would be deemed highly offensive to a reasonable person) for which Duke University assumes no responsibility.
Contains Medical Center Administrative records. These include records of the officers of the University, as defined in the Bylaws, the deans of schools and colleges, and departments, institutes, and other offices as designated by the President. For a period of twenty-five years from the origin of the material, permission in writing from the director of the office of record and the Medical Center Archivist is required for use. After twenty-five years, records that have been processed may be consulted with the permission of the Medical Center Archivist. (Issued by the Office of the Chancellor, December 1, 1975).
Materials in boxes 95, 96, 97, 131, 132, 133, 134, 135, 136, 137, 138, and 139 are restricted and can only be accessed with the permission of the Medical Center Archivist.
Boxes 94, 98, 109, 113, 114, 115, 116, 119, 120, 125, 128, 129, 140, 141, 142, 143, 144, 146, and 147 contains materials restricted at the folder level and must be screened for sensitive or confidential materials before being accessed.
For further information consult with the Medical Center Archivist..

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